Molecular Diagnostics for Personalized Medicine

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    Getting started with PathoGenius®

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    PathoGenius® offers DNA guided, personalized medicine for wound care.

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    PathoGenius® offers specifically designed Rapid screening for ENT applications and comprehensive bacterial and fungal diagnostics.

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    PathoGenius® extends rapid screen molecular diagnostics for ENT and respiratory viruses.

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    PathoGenius® offers specifically designed Rapid screening for BV as well as comprehensive bacterial and fungal diagnostics persistent infections.

 

Wound Care

 

PathoGenius® offers DNA guided, personalized medicine for wound care.

With molecular diagnostics offered by PathoGenius®, physicians are able to know exactly which micro-organisms are present in any given wound. Once the pathogenic organisms are identified, medications can be selected and ratios adjusted to specifically address the individual wound bed, thereby allowing for a precise treatment that ultimately expedites healing -- 2 to 5 times faster in most cases. These specifically developed treatments are often referred to as Personalized Medicine. Furthermore, most insurance companies cover our services.

 

The PathoGenius® Advantage in Wound Care

The dramatic advantages PathoGenius® offers over traditional culture based analysis have been clearly cited in our published work. The following are some of the findings:

 

•   99% of chronic wounds are polymicrobial, with high abundance levels.

-   This means that there are almost always many different organisms present in a wound contributing to the infected state of a wound bed. The challenge here is that many of these microorganisms are very different from each other, and require special attention.

•   Less than 5% of known wound microbes can be grown using traditional culture techniques

-   This means that the majority of the microbes (over 95%) contributing to the community of organisms within the biofilm allowing the wound to persist will NOT be detected using traditional culture techniques.

-   The limitations of traditional culture techniques lead to increased treatment cost through longer treatment times, more invasive medical interventions, and a higher incidence of progressed complications.

-   Most importantly, this leads to increased pain and suffering.

•   PathoGenius® empowers the physician to treat the bioburden with DNA level certainty.

•   The microbial Bioburden is a significant barrier for all chronic wounds, regardless of etiology

•   As a universal barrier, we must make it a universal strategy to utilize molecular diagnostics to maximize healing outcomes.

•   The microbial Bioburden is the only barrier to healing completely in the clinician’s control to manage. (Journal of Wound Care 2011; 20: 5, 232)

 

Review of Clinical Results in Wound Care

In a recent study of over 1400 wound patients, the healing rates for patients that received testing by PathoGenius® and followed the suggested treatment protocols were approximately 2 to 5 times faster! In science and medicine, there are of course no guarantees of success. However, success is dependent on the accuracy of testing information, and we can guarantee that there is no more accurate method of testing for microbial analysis than molecular DNA analysis.

 

JWoundCare 2011; 20:5, 232

 

Three groups of wound patients were monitored for 206 days: The Culture Systemic group followed traditional culture directed wound treatments. The DNA Dx/Systemic group followed traditional systemic treatments guided by molecular DNA analysis offered by PathoGenius®. The DNA Dx/Topical group of patients followed personalized topical/transdermal treatments directed by molecular DNA analysis offered by PathoGenius®.

 

 

Our Published Work in Wound Care

 

 

 

 

Dowd, Scot E., et al. "Polymicrobial nature of chronic diabetic foot ulcer biofilm infections determined using bacterial tag encoded FLX amplicon pyrosequencing (bTEFAP)." PloS one 3.10 (2008): e3326.

 

Wolcott, R. D., S. B. Cox, and S. E. Dowd. "Healing and healing rates of chronic wounds in the age of molecular pathogen diagnostics." Journal of wound care 19.7 (2010): 276-284.

 

Rhoads, Daniel D., et al. "Comparison of culture and molecular identification of bacteria in chronic wounds." International journal of molecular sciences 13.3 (2012): 2535-2550.

 

Dowd, S. E., et al. "Molecular diagnostics and personalised medicine in wound care: assessment of outcomes." Journal of wound care 20.5 (2011): 232-241.

 

Tuttle, Marie S., et al. "Characterization of bacterial communities in venous insufficiency wounds by use of conventional culture and molecular diagnostic methods." Journal of clinical microbiology 49.11 (2011): 3812-3819.

 

Wolcott, Randall D., and Garth D. Ehrlich. "Biofilms and chronic infections."JAMA: The Journal of the American Medical Association 299.22 (2008): 2682-2684.

 

Wolcott, R. D., et al. "Biofilm maturity studies indicate sharp debridement opens a time-dependent therapeutic window." journal of wound care 19.8 (2010): 320-328.

 

Wolcott, R. D., and S. E. Dowd. "A rapid molecular method for characterising bacterial bioburden in chronic wounds." Journal of wound care 17.12 (2008): 513-516.

 

Dowd, S. E., et al. "Research survey of fungi and yeast in polymicrobial infections in chronic wounds." Journal of wound care 20.1 (2011): 40-47.

 

Wolcott, Randall, et al. "Evaluation of the bacterial diversity among and within individual venous leg ulcers using bacterial tag-encoded FLX and titanium amplicon pyrosequencing and metagenomic approaches." BMC microbiology9.1 (2009): 226.

 

Wolcott, R. D., J. P. Kennedy, and S. E. Dowd. "Regular debridement is the main tool for maintaining a healthy wound bed in most chronic wounds."Journal of wound care 18.2 (2009): 54-56.

 

Dowd, S. E., et al. "Effects of biofilm treatments on the multi-species Lubbock chronic wound biofilm model." Journal of wound care 18.12 (2009): 508-512.

 

Smith, Drake M., David E. Snow, Eric Rees, Ann M. Zischkau, J. Delton Hanson, Randall D. Wolcott, Yan Sun, Jennifer White, Shashi Kumar, and Scot E. Dowd. "Evaluation of the bacterial diversity of pressure ulcers using bTEFAP pyrosequencing." BMC medical genomics 3, no. 1 (2010): 41.

 

Rhoads, Daniel D., et al. "Clinical identification of bacteria in human chronic wound infections: culturing vs. 16S ribosomal DNA sequencing." BMC infectious diseases 12.1 (2012): 321.

 

Attinger, Christopher, and Randy Wolcott. "Clinically Addressing Biofilm in Chronic Wounds." Advances in Wound Care 1.3 (2012): 127-132.

 

Wolcott, Randall D. "The effect of a hydroconductive dressing on the suppression of wound biofilm." Wounds 24.5 (2012): 132-137.

 

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