Molecular Diagnostics for Personalized Medicine

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    Getting started with PathoGenius®

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    PathoGenius® offers DNA guided, personalized medicine for wound care.

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    PathoGenius® offers specifically designed Rapid screening for ENT applications and comprehensive bacterial and fungal diagnostics.

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    PathoGenius® extends rapid screen molecular diagnostics for ENT and respiratory viruses.

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    PathoGenius® offers specifically designed Rapid screening for BV as well as comprehensive bacterial and fungal diagnostics persistent infections.

 

Ear Nose Throat and Respiratory Tract

 

Molecular Diagnostic Solutions for Chronic Infections

Bacteria grow as either individual (planktonic) cells or in complex communities of cells called biofilms. Infections caused by biofilms, often harboring many different types of micro-organisms, have been shown to be much more resistant to treatment. It is now believed that over 99 percent of all bacteria live as a community and attach to surfaces as biofilms. According to the National Institutes of Health, it is believed that approximately 80 percent of all infections in humans are related to biofilms. With molecular diagnostics offered by PathoGenius®, physicians are able to know exactly which pathogenic micro-organisms are present in any biofilm. Biofilms have been shown to play a role in many infections of the ear, nose, throat, and respiratory tract, including: ear (recurrent acute otitis media, otitis media with effusion, cholesteatoma), chronic tonsillitis, chronic pharyngitis, chronic rhinosinusitis, epiglottitis, laryngotracheitis, pneumonia, and infections of tracheostomies, endotracheal tubes, tympanostomy tubes, pulmonary infections in cystic fibrosis, chronic bronchitis and bronchiolitis.

 

The Clinical Evidence and Case for DNA Molecular Diagnosis

 

 

 

Chole, Richard A., and Brian T. Faddis. "Anatomical evidence of microbial biofilms in tonsillar tissues: a possible mechanism to explain chronicity."Archives of Otolaryngology—Head & Neck Surgery 129.6 (2003): 634.

 

Manning, Scott C. "Basics of biofilm in clinical otolaryngology." Ear, nose, & throat journal 82.8 Suppl 2 (2003): 18.

 

Coticchia, James, et al. "Biofilm surface area in the pediatric nasopharynx: chronic rhinosinusitis vs obstructive sleep apnea." Archives of Otolaryngology—Head & Neck Surgery 133.2 (2007): 110.

 

Chole, Richard A., and Brian T. Faddis. "Evidence for microbial biofilms in cholesteatomas." Archives of Otolaryngology—Head & Neck Surgery 128.10 (2002): 1129.

 

Al-Mazrou, Khalid A., and Abdulaziz S. Al-Khattaf. "Adherent biofilms in adenotonsillar diseases in children." Archives of Otolaryngology—Head & Neck Surgery 134.1 (2008): 20.

 

Perkins, Jonathan, et al. "Bacterial biofilm presence in pediatric tracheotomy tubes." Archives of Otolaryngology—Head & Neck Surgery 130.3 (2004): 339.

 

Kinnari, Teemu J., et al. "Bacterial Biofilm Associated With Chronic LaryngitisBacterial Biofilm and Chronic Laryngitis." Archives of Otolaryngology–Head & Neck Surgery 138.5 (2012): 467-470.

 

Saylam, Guleser, et al. "Association of adenoid surface biofilm formation and chronic otitis media with effusion." Archives of Otolaryngology—Head & Neck Surgery 136.6 (2010): 550.

 

Winther, Birgit, et al. "Location of bacterial biofilm in the mucus overlying the adenoid by light microscopy." Archives of Otolaryngology—Head & Neck Surgery 135.12 (2009): 1239.

 

Bendouah, Zohra, et al. "Biofilm formation by Staphylococcus aureus and Pseudomonas aeruginosa is associated with an unfavorable evolution after surgery for chronic sinusitis and nasal polyposis." Otolaryngology--Head and Neck Surgery 134.6 (2006): 991-996.

 

Macassey, E., and P. Dawes. "Biofilms and their role in otorhinolaryngological disease." Journal of Laryngology and Otology 122.12 (2008): 1273.

 

Vlastarakos, Petros V., et al. "Biofilms in ear, nose, and throat infections: how important are they?." The Laryngoscope 117.4 (2007): 668-673.

 

Smith, Angelia, Farrel Joel Buchinsky, and J. Christopher Post. "Eradicating Chronic Ear, Nose, and Throat Infections A Systematically Conducted Literature Review of Advances in Biofilm Treatment." Otolaryngology--Head and Neck Surgery 144.3 (2011): 338-347.

 

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