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PathoGenius® offers specifically designed Rapid screening for BV as well as comprehensive bacterial and fungal diagnostics persistent infections.
Bacterial Vaginitis and Yeast Infections
Vaginitis is an inflammation of the vagina, often associated with an infection. The three main types of vaginitis are bacterial vaginosis (BV), vaginal candidiasis, and trichomoniasis. Vaginal candidiasis is often referred to as a yeast infection since the infecting organism is fungal. Most often, Candida albicans is the pathogenic organism. However, there are a number of other fungi associated with human infections. Trichomoniasis is a form of vaginitis caused by the sexually transmitted single celled protozoan, Trichomonas vaginalis. BV is the most prevalent lower genital tract infection in women of reproductive age throughout the world. Millions of women are affected annually with BV, which is strongly associated with several adverse health outcomes; including preterm labor and delivery, pelvic inflammatory disease, postpartum and postabortal endometritis, and increased susceptibility to infection with various other pathogens, including Neisseria gonorrhoeae, Trichomonas vaginalis, Chlamydia trachomatis, Candida, HPV, HSV-2, and HIV-1. Abnormal vaginal discharge is often the only symptom of BV, and many women are asymptomatic.
Most microbial species that reside in the vagina cannot be cultured. Thus, with the power of next generation sequencing technology, the taxonomic composition of the vaginal microbiota and its community structure is only now becoming more understood. BV is a polymicrobial syndrome, characterized by a shift in vaginal microbiota from a predominant population of Lactobacillus spp. to a population of anaerobes; such as, Gardnerella vaginalis, Morbiluncus spp., Prevotella spp., Mycoplasma hominis and Atopobium vaginae. However, these organisms are also found in subjects who do not suffer from BV in low numbers, and thus cannot be used as a specific marker for disease.
Clinical Evidence for Molecular Diagnostics
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